Association of rs11644461 GRIN2A with clinical phenotype of schizophrenia

Introduction The glutamatergic system plays an important role in the neurobiology of schizophrenia. A lot number variants GRIN genes have been found patients with various neuropsychiatric disorders (Myers et al. F1000Res 2019; 8(F1000 Faculty Rev) 1940). GluN2A, encoded by GRIN2A gene, is most abundant GluN2 NMDA receptor subunits mammalian CNS. Clinical symptoms schizophrenia vary among individuals. gene has previously shown to be associated early onset (Poltavskaya Life (Basel) 2021; 11(10) 997). Objectives aim study was identify associations rs11644461 polymorphism features course Methods This carried out accordance Code Ethics World Medical Association (Declaration Helsinki 1975). 805 (ICD-10: F20) were included. examination and diagnostic evaluation performed using Positive Negative Syndrome Scale (PANSS). From general group patients, 2 subgroups distinguished according PANSS survey: 391 leading negative 414 positive symptoms. Also from patients: 398 a continuous 257 episodic Genotyping real-time PCR. Results An association C allele revealed (p<0,047). not disease (positive or negative). At same time, values total score on scale differed statistically significantly carriers different genotypes for this polymorphism. sum scores (Me [Q25 – Q75]) TC genotype higher (106 [92–113]) than CC (101 [87–108]) (p=0.006). Conclusions According results obtained, severity genotype. present study, it that schizophrenia, which indicates contribution locus formation disease. Disclosure Interest E. Poltavskaya Grant / Research support from: Russian Science Foundation # 21-15-00212, O. Fedorenko Kornetova I. Pozhidaev D. Paderina 21-15-00212